Our Solution: Standardized Human Tissues Produced Faster, for More Efficient Testing
Transforming 3D bioprinting with proven optics innovation
LUMINATE is our novel 3D bioprinter developed at the Goethe University as part of a Horizon 2020 consortium. Our technology allows a voxel-by-voxel print based on the principle of light sheet imaging.
We can print, but we can also image in real-time thanks to our in-line light sheet and phase contrast microscopes. This allows us to have control over the material, the cells and the print - harnessing the full power of 3D bioprinting for even more complexity.
Combined with our proprietary OptiPrintAI software, we enable fully automated quality control and reproducible tissue production, setting new standards for predictive, regulatory-ready in vitro testing.
1 Our skin models are highly viable for a minimum of 6 weeks.
2 Our gut model includes the typical lumen/Villi structure (rights: Leonie Göckes).
3 Our LUMINATE platform can create complex but reproducible test models.
High precision printing of live material
LUMINATE allows a free-floating print with 9 μm resolution and >90% cell viability, and this in a few minutes. Suitable for complex geometries that match the physiology of your patients.
Scalable, standardized close-loop platform
Compatible with industry-standard formats for a seamless integration into existing workflows. No manual handling of samples – ensuringreproducibility and minimizingcontamination.
Our team has created long-term living tissues to replace animal testing.
1 Our skin tissues can be held in culture for at least 6 weeks. The epidermis (Keratin 14 in red) and the dermis (collagen I in green) are well defined, producing a full-thickness skin equivalent for topical testing or wound assays.
2 We have created the perfect liver lobule that includes the central and portal veins. We are currently working on vascularization of the construct.
3 We can print on surfaces! Here 10 µm lines were printed on glass (hence the small imperfections visible on the slide). We also printed on SEM grids, cell culture inserts for standard well plates and some plastics.
4 Our GI tract model (intestines) is also being currently developped in cooperation with IBEC in Barcelona. The crypts and villi of the lining of the gut are crucial for the stem cells to properly do their work.
5 We can print gradients of stiffness to reproduce physiological conditions in healthy organs (for example the skin) or in case of a disease (for example in some cancers). We can then follow the movements of the cells using our built-in microscope.
